See also Antibiotics (General)
Trimethoprim (Proloprim, Trimpex) is commonly combined with sulfamethoxazole (Gantanol) for an antibiotic combination that gives a one-two punch against bacteria.
Both trimethoprim and sulfamethoxazole interfere with folate: The sulfamethoxazole makes it hard for invading bacteria to manufacture folate, and the trimethoprim makes it hard for bacteria to use the folate. The net effect is to starve the bacteria of this necessary vitamin.
The herb white willow contains substances very similar to aspirin. On this basis, it might not be advisable to combine white willow with trimethoprim or sulfamethoxazole.
Sulfa drugs can cause increased sensitivity to the sun. Various herbs, including St. John's wort and dong quai , can also cause this problem. Combined treatment with herb and drug might increase the risk further.
- Reviewer: EBSCO CAM Review Board
- Review Date: 08/2013 -
- Update Date: 08/22/2013 -