The information provided here is meant to give you a general idea about each of the medications listed below. Only the most general side effects are included, so ask your doctor if you need to take any special precautions. Use each of these medications as recommended by your doctor, or according to the instructions provided. If you have further questions about usage or side effects, contact your doctor.

Two main medications used for Lyme disease include:

  • Antibiotics
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)


Common names include:

  • Doxycycline
  • Amoxicillin
  • Cefuroxime
  • Ceftriaxone

Antibiotics are given in all stages of Lyme disease. Their aim is to kill the bacteria that cause Lyme disease. A repeat course of antibiotic therapy may be needed if Lyme disease infection recurs. Some people may continue to develop symptoms and complications of the disease even after the bacteria are killed.

  • Doxycycline—This antibiotic is given in pill form for several weeks or sometimes longer. Doxycycline can cause an upset stomach and should be taken with food. It cannot be used in pregnant women and children under 8 years of age.
  • Amoxicillin—This is a type of penicillin antibiotic. It is given to pregnant women, children under 8, and those allergic to tetracycline. It is given in pill form or liquid for children under age 8. The medication will be given over several weeks. It can be taken on an empty or full stomach.
  • Cefuroxime and ceftriaxone—These are given when you cannot take either of the other antibiotics, or if you have serious complications. Cefuroxime is usually given in pill or liquid form and should be taken with a full glass of water. They can be taken with food or a glass of milk if they upset your stomach. Ceftriaxone is given in IV form or as an injection into the muscle.

Possible side effects of all antibiotics include:

  • Abdominal pain or discomfort
  • Nausea and vomiting
  • Diarrhea
  • Allergic reaction, including skin rash, swelling, and difficulty breathing
  • Hypersensitivity to sunlight (most common with doxycycline)

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Common names include:

  • Ibuprofen
  • Naproxen

NSAIDs are pain relievers. Your doctor may advise you to use them if you have arthritis pain as a complication of Lyme disease. The dose depends on the amount of pain. For severe pain, NSAIDs are available in higher doses by prescription. They should be taken with food and a full glass of water.

Possible side effects include:

  • Increased bleeding after surgery
  • Headache
  • Upset stomach
  • Ulcers or gastrointestinal bleeding
  • Flu-like feeling
  • Asthma or chest tightness

NSAIDs may interfere with other medications including those treating high blood pressure . Be sure any doctor prescribing NSAIDs knows about your past medical history and any of your other medicines. If you are aged 50 or older or have previously had bleeding from the stomach or upper gastrointestinal tract, your doctor may prescribe different medications than the ones listed above.

Special Considerations

If you are taking medications, follow these general guidelines:

  • Take the medication as directed. Do not change the amount or the schedule.
  • Ask what side effects could occur. Report them to your doctor.
  • Talk to your doctor before you stop taking any prescription medication.
  • Plan ahead for refills if you need them.
  • Do not share your prescription medication with anyone.
  • Medications can be dangerous when mixed. Talk to your doctor if you are taking more than one medication, including over-the-counter products and supplements.

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